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NAME:
Gaurav Sahay


ADDRESS:
1030, Durham Research Center, University of Nebraska Medical Center, Omaha NE.


EMAIL AND PHONE:
gsahay@unmc.edu, 402-559-5256


EDUCATIONAL BACKGROUND:


2005-2009 PH.D (PHARMACEUTICAL SCIENCES) AT UNIVERSITY OF NEBRASKA MEDICAL CENTER,OMAHA NE

Thesis: Mechanism(s) of endocytosis for cellular entry of novel nanomaterials
2003-2005 M.S(PHARMACOLOGY) AT UNIVERSITY OF NEBRASKA MEDICAL CENTER,OMAHA NE


1999-2003 B.PHARM (BACHELORS OF PHARMACY) UNIVERSITY OF PUNE, POONA COLLEGE OF PHARMACY

RESEARCH INTERESTS

Intracellular trafficking of novel nanomaterials in different cell types
     

HONORS AND AWARDS:
First prize for best poster at Globalization of Pharmaceutics and Education Networking (GPEN) 2006 held at Lawrence, Kansas.

Outstanding poster presentation at International Nanomedicine and Drug delivery symposium (NanoDDS) 2009 held at Indianapolis, Indiana.

 

FELLOWSHIP

UNMC Bukey Fellowship

 

 PROFESSIONAL AFFILIATION:
 American Association for Pharmaceutical Sciences.


PUBLICATIONS:

 

Sahay G, Alakhova DY, Kabanov AV. Endocytosis of Nanomedicines (Review). Journal of Controlled release (submitted)

 

Sahay G, Gautam V, Luxenhofer R, Kabanov AV. The utilization of pathogen-like cellular trafficking by single chain block copolymers Biomaterials (in press)

Sahay G, Kim J, Kabanov AV, Bronich TK. The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents, Biomaterials 2009 Oct 21. Epub ahead of print


Sahay G, Batrakova E, and Kabanov A. Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport, Bioconjug. Chem., 19 (10), 2023-9, 2008


Yang Z, Sahay G, Sriadabhatala S, and Kabanov A. Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA, Bioconjug. Chem., 19 (10), 1987-94, 2008


 

RESEARCH ABSTRACTS AND PRESENTATIONS:

 

Sahay G, Vivek Gautum, Robert Luxenhofer and Alexander V Kabanov. Single chain block copolymers employ pathogen-like cellular trafficking, Poster Presentation, 7th International Nanomedicine and Drug delivery symposium (NanoDDS) Indianapolis,IN,October 2009


Sahay G, Kim JO, Kabanov AV and Bronich TK. Nanomaterial (s) - Cell Interactions: The curious case of selective entry of cross-linked micelles in cancer, Podia Presentation, Pharmaceutics Graduate Student Research Meeting (PGSRM), West Lafayette, IN, June 2009

Sahay G, Kim JO, Kabanov AV and Bronich TK. Role of caveolae mediated endocytosis in trafficking of cross linked polymeric micelles in cancer and normal cells, Poster Presentation, 2nd European Science Foundation (ESF) Nanomedicine Summer School, Lisbon, Portugal, June 2009


Sahay G, Batrakova E, and Kabanov A. Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport, Poster Presentation,6th International Nanomedicine and Drug delivery symposium (NanoDDS),Toronto, Canada, November 2008


Sahay G, Batrakova E, and Kabanov A. Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport, Poster Presentation, Gordon Research Conference Drug Carriers in Medicine and Biology, Big Sky, MT, August 2008


Sahay G, Batrakova E, and Kabanov A. Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport, Poster Presentation, Gordon Research Conference Barriers in CNS, Tilton, NH, June 2008


Sahay G, Batrakova E, and Kabanov A. Nanomaterial(s) influence trafficking mechanisms(s), Poster Presentation, 5th NanoDDS, Boston, MA, 2007


Sahay G, Batrakova E, and Kabanov A. Nanomaterial(s) influence trafficking mechanisms(s), Poster Presentation, Annual Meeting and Exposition, American Association of Pharmaceutical Scientists, San Diego, CA, November 2007


Sahay G, Batrakova E, Zhang X, Li S, and Kabanov A. Rafting with Pluronic Nanoparticles: Implications in Endocytosis, Cell Signaling and Gene Expression, Oral Presentation, Midwest Student Biomedical Research Forum, Omaha, NE, February 2007


Sahay G, Batrakova E, Zhang X, Sriadibhatala S, Li S, and Kabanov A. Pluronic P85 modulates endocytosis in Brain Endothelial Cells, Poster Presentation, Globalization of Pharmaceutics Education Network, Lawrence, KS, October 2006


Sahay G, Batrakova E, Zhang X, Sriadibhatala S, Li S, and Kabanov A. Effect of Pluronic P85 on  endocytosis in Brain Endothelial Cells, Poster Presentation, 4th NanoDDS, Omaha, NE, October 2006


Sahay G, Batrakova E, Zhang X, Li S, and Kabanov A. Effect of Pluronic on fluid phase endocytosis in Blood Brain Barrier, Poster Presentation, Pharmaceutics Graduate Student Research Meeting, Minneapolis, MN, June 2006


Sahay G, Batrakova E, Zhang X, Li S, and Kabanov A. Modulation of endocytosis by Pluronic P85 in Brain Microvessel Endothelial Cells, Oral  Presentation, Pharmaceutics Students Graduate Program, Omaha, NE, June 2006


Sahay G, Batrakova E, Zhang X, Li S, and Kabanov A. Rafting with Pluronic Nanoparticles: Implications in Endocytosis, Cell Signaling and Gene Expression, Oral  Presentation, Department of Pharmaceutical Sciences, Omaha, NE, 2006


Sahay G and Ahmad I.  Endogeneous activation of retinal stem cells, Oral Presentation, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, 2005


 

TECHNIQUES AND EXPERTISE:
DNA isolation, RNA isolation,  RTPCR, Western Blots, FACS Analysis, Confocal Analysis, Immunocytochemistry, Immunohistochemistry, Isolation of Bovine Brain Endothelial Cells and other cell culture techniques.


PAST PROJECTS:
1) “Endogeneous activation of endogeneous stem cells in the retina and perturbation of gene expression to study retinal development” Advisor Dr Iqbal Ahmad, Department of Opthalmology and Visual Sciences,Omaha NE.(M.S Advisor)


2) “Study of Acetylcholinergic antagonists in the skeletal muscle of frog”. Advisor Dr S.L. Bhodankar Department of Pharmacology, Poona College of Pharmacy, Pune, India.


3) “Bioactive Membrane Transport” Advisor(s) Dr.S.S Pisal and Dr.A.R Paradkar Department of Pharmaceutics, Poona College of Pharmacy, Pune India