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NAME:
Devika S Manickam


ADDRESS:
1020, Durham Research Center, University of Nebraska Medical Center, Omaha NE.


EMAIL AND PHONE:
dsoundara@unmc.edu
, 402-559-9021


EDUCATIONAL BACKGROUND:

BSc, Chemical Engineering (University of Madras, India)
MSc, Pharmaceutical Sciences (Advisor: Prof. David Oupický; Wayne State University, MI)
PhD, Pharmaceutical Sciences (Advisor: Prof. David Oupický; Wayne State University, MI)

 

RESEARCH INTERESTS

• Non-viral delivery systems
• Combined drug and therapeutic nucleic acid delivery
• Design of therapeutics exploiting alterations in pathological states

 

HONORS AND AWARDS:

• Merit travel grant to attend the 8 th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, Spain, 2010.

• Merit travel grant to attend the 10th and 11th Annual Meeting of the American Society of Gene Therapy, 2007 and 2008.

• Outstanding graduate student poster award, Annual Research Forum, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 2007.

PUBLICATIONS:

14 peer-reviewed publications

1 manuscript in preparation

2 review articles

1 book chapter

13 conference contributions and abstracts


A.    Peer-reviewed publications

(1)     E.G. Rosenbaugh, J. Roat, L. Gao, R-F. Yang, D.S. Manickam, J-X. Yin, H.D. Schultz, T.K. Bronich, E.V. Batrakova, A.V. Kabanov, I.H. Zucker, M.C. Zimmerman. “Nanoformulated Copper/Zinc Superoxide Dismutase Attenuates Central Angiotensin II-dependent Pressor Response and Intra-neuronal Signaling.”  Accepted for publication in Biomaterials, 2010

(2)     D.S. Manickam, J. Li, D.A. Putt, Q.H. Zhou, C. Wu, L.H. Lash and D. Oupický. “Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors.” Journal of Controlled Release, 2010, 141, 77-84.

(3)     Q.H. Zhou, C. Wu, D.S. Manickam and D. Oupický. “Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR.” Pharmaceutical Research, 2009, 26(7), 1581-1589.

(4)     L. Wan, D. S. Manickam, D. Oupický, and G. Mao. “DNA release dynamics from reducible polyplexes by atomic force microscopy.” Langmuir, 2008, 24(21), 12474-12482.

(5)     S. Kakade, D. S. Manickam, H. Handa, G. Mao, and D. Oupický. “Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles.” International Journal of Pharmaceutics, 2009, 365(1-2), 44-52.

(6)     D. S. Manickam, A. Hirata, D. A. Putt, L. H. Lash, F. Hirata and D. Oupický. “Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of reducible gene delivery vectors.” Biomaterials, 2008, 29, 2680–2688.

(7)     U. L. Rahbek, K. A. Howard, D. Oupický, D. S. Manickam, M. Dong, A. F. Nielsen, F. Besenbacher and J. Kjems. “Intracellular siRNA and Precursor miRNA Trafficking Using Bioresponsive Copolypeptides.” Journal of Gene Medicine, 2008, 10(1), 81-93.

(8)     Y-Z. You, D. S. Manickam, Q. Zhou and D. Oupický. “Dually responsive multiblock copolymers via RAFT polymerization: Synthesis of temperature- and redox-responsive copolymers of PNIPAM and PDMAEMA.”Macromolecules, 2007, 40(24), 8617-8624.

(9)     Y-Z. You, D. S. Manickam, Q. H. Zhou and D. Oupický. “A Versatile approach to reducible vinyl polymers via oxidation of telechelic polymers prepared by reversible addition fragmentation chain transfer polymerization.” Biomacromolecules, 2007, 8, 2038-2044.

(10)   Y-Z. You*, D. S. Manickam*, Q. H. Zhou and D. Oupický. “Reducible poly(2-dimethylaminoethylmethacrylate): synthesis, cytotoxicity, and gene delivery activity.” Journal of Controlled Release, 2007, 122, 217-225. (*equal contribution)

(11)   J. Blacklock, H. Handa, D. S. Manickam, G. Mao, A. Mukhopadhyay and D. Oupický. “Disassembly of Layer-by-Layer Films of Plasmid DNA and Reducible TAT Polypeptide.” Biomaterials, 2007, 28, 117-124.

(12)   D. S. Manickam and D. Oupický. “Multiblock reducible copolypeptides containing histidine-rich and nuclear localization sequences for gene delivery.” Bioconjugate Chemistry, 2006, 17, 1395-1403.

(13)   H. S. Bisht*, D. S. Manickam*, Y. You, and D. Oupický. “Temperature-Controlled Properties of DNA Complexes with Poly (ethylenimine)-graft-poly (N-isopropylacrylamide).”Biomacromolecules, 2006, 7, 1169-1178. (*equal contribution)

(14)   D. S. Manickam, H. S. Bisht, L. Wan, G. Mao and D. Oupický. “Influence of TAT-peptide polymerization on properties and transfection activity of TAT/DNA polyplexes.” Journal of Controlled Release, 2005, 102(1), 293-306.

 

B.    Manuscripts in preparation

(1)  N.L. Klyachko, D. S. Manickam*, A. M. Brynskikh, S. Li, S. M. Higginbotham, T. K. Bronich, E.V. Batrakova and A.V. Kabanov. “Nanoparticular Formulations of Antioxidant Enzymes for CNS Delivery.” (*equal contribution)

 

C.    Reviews

(1)   D. S. Manickam and D. Oupický. “Polyplex gene delivery modulated by redox potential gradients.” Journal of Drug Targeting, 2006, Sep; 14(8), 519-26.

(2)   D. Oupický, H. S. Bisht, D. S. Manickam and Q. Zhou. “Stimulus-controlled delivery of drugs and genes.” Expert Opinion on Drug Delivery, 2005, 2(4), 653-665.

 

D.    Book chapters

D. Oupický, Y. You and D. S. Manickam. “Redox-responsive polymer-based gene delivery systems.” In Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 3rd Edition, Ed. N. S. Templeton, Taylor and Francis, Boca Raton, 2007.

 

 

E.    Conference contributions and Abstracts

(1) D. S. Manickam, T. K. Bronich, A. V. Kabanov. “Bioreducible block ionomer complexes for delivery of antioxidant enzymes.” 8th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, Spain, May 2010.

(2) D. S. Manickam, L. S. Shlyakhtenko, N. L. Klyachko, E. V. Batrkova, T. K. Bronich, A. V. Kabanov. “Biophysical properties of block ionomer complexes for delivery of antioxidant enzymes.” 7th International Nanomedicine and Drug Delivery Symposium, Indianapolis, Indiana, October 2009.

(3) D. S. Manickam, L. S. Shlyakhtenko, N. L. Klyachko, E. V. Batrkova, T. K. Bronich, A. V. Kabanov. “Block ionomer complexes for delivery of antioxidant enzymes.” Oral presentation at the Center of Biomedical Research Excellence Retreat and Review, Nebraska City, Nebraska, September 2009.

(4) U. Rahbek, A. Nielsen, M. Dong, D. S. Manickam, D. Oupický, F. Besenbacher, J. Kjems, K. Howard. “Reducible Hyperbranched Polymers for siRNA Delivery.” 36th Annual Meeting of the Controlled Release Society, Copenhagen, Denmark, July 2009.

(5) J. Li, D. S. Manickam, J. Chen and D. Oupický. “Effect of Nucleic Acid Size on Physical Properties and Biological Activity of Redox-responsive Polyplexes: Plasmid DNA vs. Antisense Oligonucleotides.” 12th Annual Meeting of the American Society of Gene Therapy, San Diego, California, May 2009.

(6) D. S. Manickam, D. A. Putt, S. Banerjee, F. Sarkar, L. H. Lash and D. Oupický.  "Effect of innate glutathione levels on activity of redox-sensitive gene delivery systems." Oral presentation at the 35th Annual Meeting of the Controlled Release Society, New York, NY, July 2008.

(7) D. S. Manickam, A. Hirata, D. A. Putt, F. Sarkar, L. H. Lash, F. Hirata and D. Oupický. "Overexpression of Bcl-2 as a proxy redox stimulus to enhance activity of reducible gene delivery vectors." Oral presentation at the 11th Annual Meeting of the American Society of Gene Therapy, Boston, MA, June 2008.

(8) D. S. Manickam, A. Hirata, D. A. Putt, F. Sarkar, L. H. Lash, F. Hirata and D. Oupický. “Bcl-2 over-expression as a proxy stimulus to modulate activity of redox-sensitive polyplexes for cancer gene therapy.” Oral presentation at the 10th Annual Meeting of the American Society of Gene Therapy, Seattle, WA, June 2007.

(9) J. Blacklock, H. Handa, D. S. Manickam, G. Mao, A. Mukhopadhyay and D. Oupický. “Disassembly of reducible TAT polypeptide films for controlled DNA release.” Society of Biomaterials Annual Meeting, Chicago, IL, April 2007.

(10) D. Oupický, Y. You, D. S. Manickam and Q. Zhou. “Gene Delivery Modulated by Redox Potential Gradients.”13th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, February 2007.

(11) H. Kaur, D. S. Manickam and D. Oupický. “Synthesis of polycations with reducible disulfide bonds in the backbone and their use in nucleic acid delivery.” 232nd€S National Meeting, San Francisco, CA, September 2006.

(12) J. Blacklock, H. Handa, D. S. Manickam, G. Mao, A. Mukhopadhyay and D. Oupický. “Disassembly of Layer-by-Layer Films of Plasmid DNA and Reducible Tat Polypeptide.” 2006 Annual Meeting of the American Institute of Chemical Engineers, San Francisco, CA, November 2006.

(13) D. S. Manickam, H. S. Bisht and D. Oupický. “Potential of multiblock reducible copolypeptides as safe and efficient gene delivery vectors.” 32nd Annual meeting of the Controlled Release Society, Miami, FL, June 2005.

 

What do you do when you are not in the lab?


Miss lab

 

Where are you from? How many languages do you speak?  

Chennai, India (Tamil and English)

 

List interesting facts about you:  

I still very badly miss my grad school life!