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NAME:
Xiang Yi


ADDRESS:
1030, Durham Research Center, University of Nebraska Medical Center, Omaha NE.


EMAIL AND PHONE:

xyi@unmc.edu, 402-559-5256


EDUCATIONAL BACKGROUND:

2005 – 2010  Ph.D. (Major: Pharmaceutical Sciences, Minor: Protein Brain Delivery)  University of Nebraska Medical Center (UNMC), Omaha, NE
                  Advisor: Alexander V. Kabanov 
1995 - 1999  B. S. in Pharmaceutical Sciences – Peking University Health Science Center, Beijing, China
 

RESEARCH INTERESTS:

I am a 5rd year graduate student of Pharmaceutical Sciences Graduate Program. I am working on protein modification with a block polymer Pluronic to enhance protein intracellular delivery and brain delivery. Protein drugs are potential pharmaceutical agents for the treatment of many central nervous system (CNS) disorders. However, they generally do not cross the blood-brain barrier (BBB) due to poor lipophilicity and/or large molecular mass and/or absence of specialized BBB receptor-mediated transport system. In some other cases, penetration of neuronal cell membranes is crucial for proteins to exert the function and provide therapeutic efficacy. My work is to synthesize Pluronic-protein conjugates using degradable or non-degradable linkers, characterize the products using various methods including MALDI-TOF, SDS-PAGE, IEF, WB, ELISA, SPR, AFM and activity assays, and determine the Pluronic-protein intracellular delivery and brain delivery in vitro and in vivo. In particular, I have been working in the following three projects:
I. Horseradish peroxidase (HRP) modification by Pluronic for enhanced uptake in and transport across the bovine brain microvessel endothelial cell monolayers (BBMEC).
II. Pluronic-Modified Superoxide Dismutase 1 (SOD1) Attenuates Angiotensin II-Induced Increase in Intracellular Superoxide in Neurons
III. Pluronic modified leptin to across the BBB and for the treatment of obesity. 

 

HONORS AND AWARDS:

• NanoDDS’09 Poster Award for Outstanding Scientific Poster Display and Oral Presentation, Nanomedicine and Drug Delivery Symposium (NanoDDS’ 09) 2009
• American Heart Association (AHA) Midwest Predoctoral Fellowship 2009-2011
• UNMC Graduate Fellowship, 2006-2009
• Servier Young Investigator Award in Medicinal Chemistry, Institute de Recherches Internationales Servier, 2003
• Liang Huang Zhou Yu Young Investigator Award, Institute of Materia Medica CAMS&PMUC, 2001
• Outstanding Undergraduate Award, Peking University Health Science Center, 1999
• Excellent Undergraduate Thesis Award, Peking University Health Science Center, 1999
• Excellent Academic Scholarship, Peking University Health Science Center, 1996-1998

PUBLICATIONS:

• Yi, X., Zimmerman, M.C., Yang, R.; Tong, J., Vinogradov, S., Kabanov, A.V. Pluronic-Modified Superoxide Dismutase 1 (SOD1) Attenuates Angiotensin II-Induced Increase in Intracellular Superoxide in Neurons. Free Radical Biology & Medicine. 2010. Accepted.
• Price TO, Farr SA, Yi X, Vinogradov S, Batrakova EV, Banks WA, Kabanov AV. Transport Across the Blood-Brain Barrier of Pluronic Leptin. J Pharmacol Exp Ther. 2010 Apr; 333(1):253-63.
• Yi, X., Batrakova, E., Banks, W. A., Vinogradov, S., and Kabanov, A. V. Protein Conjugation with Amphiphilic Block Copolymers for Enhanced Cellular Delivery. Bioconjug Chem. 2008 May;19(5):107.
• Gilmore, J. L., Yi, X., Quan, L., and Kabanov, A. V. Novel Nanomaterials for Clinical Neuroscience. J Neuroimmune Pharmacol. 2008 Jun;3(2):83. Equal contribution for the first and second author.
• Wenhui Hu, Zongru Guo, Xiang Yi, Changbin Guo, Fengming Chu, Guifang Cheng. Discovery of 2-Phenyl-3-sulfonylphenyl-indole Derivatives as a New Class of Selective COX-2 Inhibitors. Bioorganic & Medicinal Chemistry. 2003 Vol(11):5539.
• Changbin Guo, Xiang Yi, Zongru Guo and Zhibing Xu. The Study on Molecular Mechanism and COX-2 Selectivity of Flurbiprofen Derivative, Acta Chimica Sinica, 2003 Vol 61:1653.
• Xiang Yi, Zongru. Guo, Feng Ming. Chu. Study on Molecular Mechanism and 3D-QSAR of Influenza Neuraminidase Inhibitors. Bioorganic & Medicinal Chemistry, 2003, Vol(11): 1465.
• Peicheng Zhang, Yinghong Wang, Xin Liu, Xiang Yi, Ruoyun Chen, Dequan Yu. Conformation Study of 8-glucosyl-prunetin by Dynamic NMR Spectroscopy, Chinese Chemical Letters, 2002, 13:645.
• Zongru Guo, Xiang Yi, Zhibing Xu. Molecular Simulation of Interaction Between Estrogen Receptor and Selective Estrogen Receptor Modulators. Acta Pharmacologica Sinica, 2002, V23(3):208.
• LI Wei, YI Xiang, GUO Zong-Ru et al. 3D-QSAR Study of Wu Wei Zi for Anti-AIDS Using Comparative Molecular Similarity Indices Analysis. Acta Chimica Sinica, 2002, Vol 60: 1311.
• Shengb Wan, Xiang Yi, Zongru Guo. Three Dimensional Quantitative Structure--Activity Relationship of A Series of Benzocylohept-apyridine Farnesyl Transferase Inhibitors. Acta Pharmaceutica Sinica, 2002,37:257.
• Xiang Yi, Zongru Guo. Three Dimensional Quantitative Structure--Activity Relationship of PPARγ Agonists. Acta Pharmaceutica Sinica, 2001, Vol 36: 262
• Zongru Guo, Xiang Yi, Minmin Wang, Fengming Chu. Molecular Modeling and QSAR Studies on the Interaction Mechanism of Retinoids Binding to RXR. Acta Chimica Sinica, 2001, Vol 59: 1925.
• Shengb Wan, Xiang Yi, Zongru Guo. Three Dimensional Quantitative Structure--Activity Relationship of Farnesyl Protein Transferase Inhibitors. Acta Pharmaceutica Sinica, 2001, Vol 36: 423
• Jie Wang, Qiang Zhang, Xiang Yi, et al. Effect of Surface Modification on the Uptake of Polylactic Acid Nanoparticles Loading Cyclosporine A by Cells in vitro and on the Body Distribution in vivo. Journal of Beijing Medical Univeristy, 2000, Vol 32:235.

What do you do when you are not in the lab?

I enjoy my research very much because it fits my curiosity about science and I have chance to meet interesting people in this field. Outside of science, I like to travel, play volleyball and ping pong, and watch movies.

 

Where are you from? How many languages do you speak?  

From china.